Targeted Protein Degradation

1. Biochemistry or cell-based assays and assay development/validation for TPDs, PROTACS, LYTACS, AUTACS, RIBOTACS, and molecular glues

2. High content screening (HCS) for new drug targets or lead compounds

3. Full automated  HCS setup

Solution for targeted protein degradation assay​:

1. Target-Degrader Or E3-Degrader Binary Or Target-E3 Ligase Ternary Binding Assay

   • TR-FRET, FP, AlphaScreen, NanoBiT, NanoBRET

2. Target Ubiquitination Assay

   • TR-FRET, Pulldown-WB, NanoBRET

3. Target Degradation Assay

   • HiBiT, In-Cell-Western, ELISA, AlphaLISA, TR-FRET, WB/JESS, FACS

4. HiBiT KI/Overexpression Cell Line Generation